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Spatially, the mid-peripheral and peripheral RGCs are more vulnerable in experimental glaucoma in pigs and rats [117, 159, 160]

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The bifunctional complex according to claim 15, wherein phosphate derivatization generate a phosphorothiote, a phosphodithioate, a methylphosphonate, a phosphoramidate, a phosphotriester, or a non-phosphorous-containing linkage